1. Metabolic Enzyme/Protease
  2. MMP
  3. Histatin 5 TFA

Histatin 5 TFA  (Synonyms: 富组蛋白5三氟乙酸盐)

目录号: HY-P0273A 纯度: 99.98%
COA 产品使用指南

Histatin 5 TFA 抑制宿主基质金属蛋白酶 MMP-2MMP-9 活性,IC50s 分别为 0.57 和 0.25 μM。

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Custom Peptide Synthesis

Histatin 5 TFA Chemical Structure

Histatin 5 TFA Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
500 μg ¥1200
In-stock
1 mg ¥1800
In-stock
5 mg ¥4300
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Histatin 5 TFA:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.

IC50 & Target

IC50: 0.57 μM (MMP-2), 0.25 μM (MMP-9)

体外研究
(In Vitro)

Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. To localize the domain responsible for this inhibition, three peptides containing different regions of Histatin 5 are synthesized and tested as inhibitors of MMP-9. Peptides comprising residues 1 to 14 and residues 4 to 15 of Histatin 5 show much lower inhibitory activities (IC50s, 21.4 and 20.5 μM, respectively), while a peptide comprising residues 9 to 22 showed identical activity to Histatin 5 against MMP-9. Kinetic analysis of the inhibition of the Arg-gingipain reveals that Histatin 5 is a competitive inhibitor, affecting only the Km with a Ki of 15 μM [1]. Histatin 5 is an inhibitor of mitochondrial respiration.The human salivary antifungal peptide Histatin 5 is taken up by Candida albicans cells and associates intracellularly with mitochondria. Histatin 5 inhibits respiration of isolated C. albicans mitochondria as well as the respiration of intact blastoconidia in a dose and time-dependent manner. Histatin 5 at a concentration of 33 uM inhibits state 2 respiration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3150.31

Formula

C135H196N51F3O35

性状

固体

颜色

White to off-white

Sequence

Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr

Sequence Shortening

DSHAKRHHGYKRKFHEKHHSHRGY

中文名称

富组蛋白5三氟乙酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

H2O 中的溶解度 : 100 mg/mL (31.74 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.3174 mL 1.5871 mL 3.1743 mL
5 mM 0.0635 mL 0.3174 mL 0.6349 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.98%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3174 mL 1.5871 mL 3.1743 mL 7.9357 mL
5 mM 0.0635 mL 0.3174 mL 0.6349 mL 1.5871 mL
10 mM 0.0317 mL 0.1587 mL 0.3174 mL 0.7936 mL
15 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5290 mL
20 mM 0.0159 mL 0.0794 mL 0.1587 mL 0.3968 mL
25 mM 0.0127 mL 0.0635 mL 0.1270 mL 0.3174 mL
30 mM 0.0106 mL 0.0529 mL 0.1058 mL 0.2645 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Histatin 5 TFA
目录号:
HY-P0273A
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